Glutathione depression by dihydropyrazine derivative
نویسندگان
چکیده
منابع مشابه
Oxidative stress induced by a dihydropyrazine derivative.
The Maillard reaction contributes to the complications of diabetes and normal aging. Dihydropyrazines (DHPs), which are produced during the Maillard reaction, generate radicals and possess DNA strand-cleaving activities in vitro. In the present study, we evaluated the genotoxic and cytotoxic potentials of a DHP derivative, cyclohexyl-DHP, which is obtained as a mixture of two isomers, 2,3,5,6,7...
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متن کاملDihydropyrazine-induced inactivation of glyceraldehyde-3-phosphate dehydrogenase.
Dihydropyrazine (DHP), which is produced during the Maillard reaction, generates radicals that not only cause breakage of chromosomal DNA leading to mutagenic lesions but also induce oxidative damage to cellular proteins. In the present study, we show that three DHP derivatives, which generated superoxide anions, caused inhibition of glyceraldehyde-3-phosphate dehydrogenase (GAPDH). SH-compound...
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ژورنال
عنوان ژورنال: The Journal of Toxicological Sciences
سال: 2011
ISSN: 0388-1350,1880-3989
DOI: 10.2131/jts.36.231